evaluation of the effect of taurine on cisplatin-induced hepatic injury and oxidative stress in male rats

introduction: the principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. this study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. methods: male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): group that received taurine (200 mg/kg ip) for 1hr before cisplatin (10 mg/kg ip) administration (4): taurine treated group (200 mg/kg ip). after 7 days, the animals were sacrificed and blood samples collected from the heart as well as liver tissues were kept at -70 °c till further analyses. results: analyses showed that cisplatin significantly increased alt and ast serum levels (p<0.05) while pretreatment with taurine resulted in the reduction of these markers. catalase activity in cisplatin-treated rats was significantly decreased (p<0.05) and taurine administration could recover this reduction. mda content of the liver tissue was significantly increased in cisplatin-exposed animals, while taurine treatment reduced the amount of mda in liver tissue. conclusion: our data suggest that taurine prevents from cisplatin-induced hepatic injury and this effect may be due to its antioxidant properties.